Sung In Lim,Myung Hyun Jang,Dae Jin Kim,Sung Youb Jung,Se Chang Kwon
申请号：
US14123258
公开号：
US09944688B2
申请日:
2012.06.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a non-peptidyl polymer-insulin multimer comprising two or more of a non-peptidyl polymer-insulin conjugate prepared by linking a non-peptidyl polymer and insulin via a covalent bond, in which the conjugates are complexed with cobalt ion to form a multimer, a method and kit for the preparation of the multimer, a pharmaceutical composition for the prevention or treatment of diabetes comprising the multimer as an active ingredient, and a method for preventing or treating diabetes by administering the composition to a subject.
