Compositions and methods of use for cell targeted inhibitors of the Cystic Fibrosis transmembrane regulator associated ligand

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专利权人:

Andrew Peter Mallon

发明人:

Andrew Peter Mallon,Alvin C. Bach, II

申请号：

US14229851

公开号：

US20140296164A1

申请日:

2014.03.29

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The present invention describes peptide drugs that inhibit the interaction between CAL and CFTR, and other proteins in cystic fibrosis and other diseases. These invented drugs have been chemically optimized to impart solubility, stability, cell permeability, mucus penetration, intracellular targeting and sequestration, increased potency and non-immunogenicity, while conserving and imparting efficacy. This renders these compositions suitable for human use, which is exemplified by use in the treatment of cystic fibrosis.

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