Thomas Leonard Joseph,Chandra Shekhar Verma,David Phillip Lane,Christopher John Brown
申请号：
US14432729
公开号：
US20150246946A1
申请日:
2013.10.01
申请国别(地区):
US
年份:
2015
代理人:
摘要：
By using a phage display derived peptide as an initial template, compounds have been developed that are highly specific against Mdm2/Mdm4. These compounds exhibit greater potency in p53 activation and protein-protein interaction assays than a compound derived from the p53 wild-type sequence. Unlike nutlin, a small molecule inhibitor of Mdm2/Mdm4, the phage derived compounds can arrest cells resistant to p53 induced apoptosis over a wide concentration range without cellular toxicity, suggesting they are highly suitable for cyclotherapy.
