Cornell University;The Research Foundation For The State University Of New York
发明人:
Ronald G. Crystal,Todd K. Rosengart,Robert Gersch,Megumi Mathison
申请号：
US14439357
公开号：
US10383916B2
申请日:
2013.11.01
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided is a method of treating coronary artery disease in a mammal, comprising administering to a region of the heart of the mammal (a) a first vector encoding one or more angiogenic proteins which induce vascularization in the heart of the mammal, and (b) a second vector encoding one or more cardio-differentiating transcription factors which induce the production of induced cardiomyocytes (iCM) in the heart of the mammal, whereby the coronary artery disease in the mammal is treated. In a preferred embodiment, the first vector is an adenoviral vector encoding VEGF and the second vector is a lentiviral vector encoding Gata4, Mef2c, and Tbx5 (GMT).
