Chae Ha Yoon;Seung Kook Park;Joon Pio Hong;Kyeong Sun Shin;Sang Wook Lee;Sang Kil Lee;Won Chul Kim
发明人:
Joon Pio Hong,Sang Kil Lee,Won Chul Kim,Chae Ha Yoon,Sang Wook Lee,Kyeong Sun Shin,Seung Kook Park
申请号：
US12375739
公开号：
US08685440B2
申请日:
2007.08.01
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a nanoliposome comprising a liposome membrane containing esterified lecithin, and one or more physiologically active ingredients included in inner space of the liposome membrane； a method for preparing the same； and a composition for preventing or treating skin diseases, comprising the same. The nanoliposome according to the present invention has long-term stability and uniformity, and so can be used to prepare a composition for skin having excellent moisturizing and penetrating properties, such as cosmetics, medicament for treating skin diseases, or the like. In particular, the present composition for preventing or treating skin diseases comprises epidermal growth factor included in the nanoliposome, thereby showing an excellent effect of stimulating skin-penetration and good pharmaceutical stability. Also, the esterified lecithin used in preparing liposome can provide effects of softening skin and stimulating skin-penetration, thereby enhancing the penetration of epidermal growth factor and natural extract into skin, as well as additional moisturizing effect which is advantageous in treating skin diseases. Further, since the present composition comprises nanoliposome prepared by containing esterified lecithin in liposome membrane, the conventional problems of heating and dispersing active ingredients at high temperature (70° C. or more), low stability and uniformity, or the like can be solved.
