Rama Haldar,Dipan B. Ray,Timothy G. Bee,Sidney Etienne,Su-Jane Cheng
申请号：
US11290715
公开号：
US08168219B2
申请日:
2005.11.30
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Tablets of a pharmaceutical, nutritional or vitamin active compound or composition, e.g. a poorly compressible drug are made by direct compression using a synergistic binder composition of co-processed (a) copolymer of vinylpyrrolidone (VP) and vinyl acetate (VA) and (b) microcrystalline cellulose (MCC), in a wt. ratio of (a):(b) of 1-30:99-70, which is spray dried to provide a readily compressible excipient binder powder for such active. The tablets obtained herein have advantageous hardness and friability at an acceptable compression force.
