Short, Jay M.,Chang, Hwai Wen,Frey, Gerhard,Frost, Gregory
申请号：
AU2010222818
公开号：
AU2010222818B2
申请日:
2010.03.09
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at the wild type normal physiological conditions. For example, evolved proteins are virtually inactive at body temperature, but are active at lower temperatures.
