An alignment frame for use in weight bearing imaging of a knee or knees, the alignment frame includes a base with a support extending upward from a base. A thigh positioner is attached to the support. The thigh positioner includes a panel portion for contact by a user's thigh, and an imaging portion located below the panel portion. The imaging portion is made from material that does not interfere with imaging transmissions, such as x-rays and MRI transmissions (e.g., made from x-ray compatible and/or MRI compatible materials). At least one foot alignment device is on the base. The foot alignment device includes at least one foot positioner with an inner wall and a toe wall, the inner wall extending medially away from the toe wall.
