Devices, systems, and methods to precondition, arterialize, and/or occlude a mammalian luminal organ. In an exemplary embodiment of a device, the device comprises a frame comprising a plurality of struts and configured for expansion, and a covering surrounding at least an external perimeter of the frame, the covering comprising an impermeable material, wherein the device is configured for expansion without requiring the introduction of a gas and/or a liquid therein.
