The present invention provides an oligomeric prophylactic for treating medical disorders such as glaucoma, disorders or abnormalities associated with increased intraocular pressure (IOP), disorders requiring neuroprotection, age-related macular degeneration, or diabetic retinopathy. Provided are new prodrugs of therapeutically active compounds, including drugs and compositions. [Selection diagram] Fig. 36本発明は、医学的障害、例えば緑内障、眼内圧(IOP)の増大に関連する障害若しくは異常、神経保護を必要とする障害、加齢黄斑変性、又は糖尿病性網膜症を治療するためのオリゴマープロドラッグ及び組成物を含む治療活性化合物の新たなプロドラッグを提供する。【選択図】図36