Disclosed herein is the use of compounds of formula IC or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of cancer. Also disclosed is the use of these compounds in combination with another known anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.
