The University Of Tokyo;Kawasaki Institute of Industrial Promotion
发明人:
申请号：
EP18851853.4
公开号：
EP3677268A1
申请日:
2018.08.30
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention provides a unit-type polyion complex, comprising: a specific number of molecules of a block copolymer having a poly(ethylene glycol) segment and a cationic poly(amino acid) segment； and a specific number of molecules of a nucleic acid, wherein a total positive charge quantity derived from side chains of the cationic poly(amino acid) segment of the block copolymer in the unit-type polyion complex is prevented from being counterbalanced with a total negative charge quantity derived from the nucleic acid, wherein the nucleic acid has a strand length of from 10-base length to 50-base length, wherein the poly(ethylene glycol) segment has a molecular weight of 40×103 or more, and wherein the block copolymer has a binding constant (Ka) for the nucleic acid of 3.0×105 or more.
