The present invention provides a kind of newfound furodiazole antibiotic. The oxadiazoles can damage cell wall and synthesize and show active resisting gram-positive bacterium, such as staphylococcus aureus (Staphylococcus aureus), the staphylococcus aureus of staphylococcus aureus (MRSA) and vancomycin resistance and Nai Leinaizuoli including methicillin-resistant. For example, 5- (1H- indoles -5- bases) -3- (4- (4- (trifluoromethyl) phenoxy group) phenyl) -1,2,4- oxadiazoles (antibiotic 75b) is effectively, to show long half-lift, high distribution volume and low removing in the mouse model that MRSA infects. Antibiotic 75b has bactericidal effect and is that oral bio is compatible. This kind of antibiotic can be used as the therapeutic agent of resisting gram-positive bacterium such as MRSA infection.