PATRICK ROBERT VERHOEST,THOMAS ALLEN CHAPPIE,NANDINI CHATURBHAI PATEL,MATTHEW MERRILL HAYWARD
申请号：
ARP140100515
公开号：
AR094702A1
申请日:
2014.02.18
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Compounds that can be used to treat SNC, metabolic and autoimmune disorders. 1. Requirement 1: a compound (1) with formula characteristics,O salts are pharmaceutical salts, among which: R1 is represented by alternatives selected from a group consisting of cyclo-c83231 / 83321；Non propylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylC₆₋₁₀ aryl and heteroaryl (5 to 10 members)；where C ciclo cycloalkyl,C₆₋₁₀ aryl and heteroaryl (5 to 10 members) are optionally substituted with (R²) ᵇ；and the heterocycloalkyl (4 to 10 members) is optionally substituted in 1 to 5 carbon atoms with a substituent independently selected from the group consisting of halogen, C₁₋₆ alkyl,C₁₋₆ haloalkyl,C₁₋₆ alkoxy,hello Coxi C₁₋₆,C₁₋₆tio alkyl, -C (O) NR⁴R⁵,hydroxy and cyano； and optionally substituted, at each available nitrogen, with C₁₋₆ alkyl；R² is represented by a substituent independently selected from the group consisting of halogen, C₁₋₆ alkyl,C₁₋₆ haloalkyl,C₁₋₆ alkoxy,hello Coxi C₁₋₆,C 1-10 alkyl； -C (O) NR⁴R⁵,Hydroxy and cyanogen； R3,if present, in each case it is represented by a substituent independently selected from the group consisting of halogen, C₁₋₆ alkyl,C₁₋₆ haloalkyl,C₁₋₆ alkoxy,hello Coxi C₁₋₆,C₁₋₆tio alkyl, -C (O) NR⁴R⁵,a. Hydrogen Xi and cyanogen； each r8308y and r83099 is represented by selected alternatives independent of the hydrogen group；Each r8310a and r8311a is represented by an alternative independent of the hydrogen group；- (CH) -cicloalquilo C-(ch832222) - 834483； - isopropylpropylpropyl (4-10 members),-(ch832244)； - arilo c8332626-83318321； - 8320y - (ch832222) - 8344； - heterogeneous (5-10 members)；There, I rented c832183.31832626,C₃₋₁₀ cycloalkyl,C₆₋₁₀ aryl and heteroaryl (5 to 10 members) are optionally substituted with 1 to 5 substituents independently selected from the group consi
