Robert F. Reder,Paul D. Goldenheim,Robert F. Kaiko
申请号：
US14847211
公开号：
US20160220559A1
申请日:
2015.09.08
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A method of effectively treating pain in humans is achieved by administering buprenorphine in accordance with first order kinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained, and thereafter maintaining the administration of buprenorphine for at least an additional two-day dosing interval in accordance with substantially zero order kinetics, such that the patients experience analgesia throughout the at least two-day additional dosing interval.
