Ofer MANDELBOIM,Noa S. KAYNAN,Pinchas TSUKERMAN,Stipan JONJIC
申请号：
US15756606
公开号：
US20180185480A1
申请日:
2016.09.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided is a natural killer (NK) cell killing of various tumors is inhibited in the presence of ligands of TIGIT, an inhibitory receptor present on all human NK cells and on various T cells. Monoclonal antibodies that recognize TIGIT and inhibit its suppressive activity on T-cells are provided as well as pharmaceutical compositions including them and methods for their use in cancer immunotherapy and in diagnosis and treatment of immune disorders.
