The present disclosure relates a multi-leaf collimator. The multi-leaf collimator may include a plurality of leaf modules. Each leaf module of the plurality of leaf modules may include a leaf configured to shield a portion of beams emitted by a radiation source. The leaf may be movable along a guide rail of the multi-leaf collimator. Each leaf module may also include a drive mechanism including a first drive component and a second drive component. The first drive component and the second drive component may be both connected to the leaf. The first drive component and the second drive component may jointly actuate the leaf to move along the guide rail.