APITOPE INTERNATIONAL NV;APITOPE TECHNOLOGY (BRISTOL) LIMITED;MERCK SERONO S.A.
发明人:
申请号：
IL23987015
公开号：
IL239870A
申请日:
2015.07.09
申请国别(地区):
IL
年份:
2018
代理人:
摘要：
There is provided a peptide which is capable of binding to an MHC molecule in vitro and being presented to a T cell without antigen processing (i.e. an apitope) which peptide comprises all or a portion of the following proteolipid protein (PLP) peptides: PLP 36-61: HE ALTGTEKLIET YF SKN YQD YEYLI (SEQ ID NO. 1) PLP 179-206: TWTTCQSIAFPSKTSASIGSLCA DARMY (SEQ ID NO. 2) PLP 207-234: GVLPWNAFPGKVCGSNLLSICKTAEFQM (SEQ ID NO. 3). There is also provided the use of such a peptide in a pharmaceutical composition and a method to treat and/or prevent a disease using such a peptide.
