A compound according to the general Formula (Ia) or the General Formula (Ib): ** Formula ** a salt by the addition of pharmaceutically acceptable acids or bases thereof, a quaternary amine thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or an N-oxide thereof, wherein: p is an integer equal to zero, 1, 2, 3 or 4； q is an integer equal to 1, 2 or 3； Z is a radical selected from the formulas: ** Formula ** or ** Formula ** R1 is cyano, halo, alkyl, haloalkyl, hydroxy, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, arylalkyl, di (aryl) alkyl, aryl or Het； R2 is hydrogen, alkyloxy, aryl, aryloxy, hydroxy, mercapto, alkyloxyalkyloxy, alkylthio, mono- or di- (alkyl) amino, pyrrolidine or a radical of formula ** Formula ** wherein Y is CH2, O, S, NH or N-alkyl； R3 is alkyl, arylalkyl, aryl, mono- or di-alkylaminoalkyl, Het or Het-alkyl； R4 and R5, each independently, is hydrogen； I rent； alkyloxyalkyl； arylalkyl； Het-alkyl； monoo di-alkylaminoalkyl； Het； or aryl； or R4 and R5, together with the nitrogen atom to which they are attached, form a radical selected from the group consisting of pyrrolidino, piperidino, piperazino, morpholino, 4-thiomorpholino, 2,3-dihydroisoindole-1-yl, thiazolidin-3- yl, 1,2,3,6-tetrahydropyridyl, 1,4-diazacycloheptyl, 1-aza-4-oxocycloheptyl, 1,2,3,4-tetrahydroisoquinolin-2-yl, 2H-pyrrolyl, pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2- pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl optionally substituted with one or more substituents, each of the alkyl, haloalkyl, halo, arylalkyl substituents being independently selected hydroxy, alkyloxy, amino, mono- or di-alkylamino, alkylthio, alkyloxyalkyl, alkylthioalkyl, aryl, pyridyl or pyrimidinyl； R6 is aryl or Het； R7 is hydrogen, halo, alkyl, aryl or Het； R8 is a saturated, linear or branched hydrocarbon radical having 1 to 6 carbon atoms； R9 is hydrogen or alkyl； R10 is oxo； and X
