A new and distinct cultivar of Hydrangea macrophylla (Thunb.) named ‘Peppermint Twist’ originated as a controlled cross between the unpatented variety ‘Sabrina’ (the seed parent) and the patented variety ‘Glory’ (U.S. Plant Pat. No. 20,705). The cultivar ‘Peppermint Twist’ has predominately white sepals (R.H.S. 155 C (white group) with edges of R.H.S. 63 A (red-purple group). The variety ‘Peppermint Twist’ has large attractive inflorescences, distinct sepal pigmentation and good commercial characteristics.