The present invention relates to an application of using memantine to prepare a medicine capable of inhibiting the activity of internal ribosome entry site (IRES) of entervirus 71, and a medicine composition used to inhibit the IRES activity of entervirus 71. This medicine composition includes an effective dose of memantine and a pharmaceutically acceptable carrier to treat Entrervirus 71 infection.The concentration of memantine for inhibiting the IRES activity of Entervirus 71 is 0.1 &mgr m to 10 &mgr m. When the memantine is used to inhibit the IRES activity of Entrervirous 71, it does not affect the cap-dependent translation in an object infected by Entrervirous 71.The object is mammal, such as human being.本發明係關於一種美金剛胺(Memantine)於製備用於抑制腸病毒71型之內部核糖體結合位置(internal ribosome entry sites,IRES)活性之藥物的應用,以及用於抑制腸病毒71型之內部核糖體結合位置活性之醫藥組成物,包含一有效劑量之美金剛胺以及一藥學上可接受之載體,以治療腸病毒71型感染。其中美金剛胺抑制腸病毒71型之內部核糖體結合位置活性之濃度為0.1μM~10μM,且美金剛胺於抑制腸病毒71型之內部核糖體結合位置活性時,不會影響受腸病毒71型感染之一個體的帽依賴型轉譯(cap-dependent translation)作用,該個體係為一哺乳類動物例如人類。
