An orthodontic space closure device is provided, including a first tooth cap unit, a second tooth cap unit, and a number of elastic members. The first tooth cap unit is configured to be removably worn on the anterior teeth of a dental arch of a patient. At least one first connector is fixed on each buccal side of the first tooth cap unit. The second tooth cap unit is configured to be removably worn on the posterior teeth of the dental arch. A vertical extension part is formed on each buccal side of the second tooth cap unit, and at least one second connector is fixed on each vertical extension part. The elastic members couple the first connectors to the second connectors, thereby exerting elastic traction forces having horizontal and vertical components on the first tooth cap unit to achieve retraction and intrusion of the anterior teeth.