An electrode patch module, a chronic pain detection method and an apparatus thereof are provided. The electrode patch module affixed at a zone to be tested contains at least three electrode pads. The chronic pain detection apparatus selects multiple electrode pairs from the electrode pads and uses the electrode pairs to measure the zone to be tested so as to obtain multiple characteristic values of different muscle areas. The chronic pain detection apparatus receives the characteristic values for performing comparison operations to produce a result for assistant judging where the chronic pain may have in the zone to be tested.