The present invention provides a controlled release delivery dosage form for controlled release of an active ingredient, comprising an active ingredient embedded in a polymeric mixture of: o at least one water insoluble polymer and o a starch derivative composition of at least one component selected from the group consisting of indigestible oligosaccharides, modified starches and legume starches, wherein the polymeric mixture provide the release of said active ingredient in the colon of patients having a Dysbiosis and in the colon of healthy subjects. The present invention also relates to the use and method for making the same.
