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Biaryl-propionic acid derivatives and their use as pharmaceuticals
专利权人:
Sanofi
发明人:
Ruf, Sven,Sadowski, Thorsten,Wirth, Klaus,Schreuder, Herman,Buning, Christian,Kallus, Christopher,Strobel, Hartmut,Wehlan, Hermut
申请号:
AU2014243069
公开号:
AU2014243069B2
申请日:
2014.03.26
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
The present invention relates to compounds of the formula (I), wherein X, R, R1, R2, D, E1, E2, E3, E4, G1, G2, G3 and G4 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
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