The United States of America; as represented by the Secretary; Department of Health and Human Services
发明人:
Dennis J. Kopecko,Manuel Osorio,Monica R. Foote
申请号：
US14402457
公开号：
US09409956B2
申请日:
2013.05.22
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Described herein is the generation of a plasmid construct for expression of a Yersinia pestis F1-V fusion protein. In the disclosed plasmid, the F1-V fusion protein coding sequence is operably linked to the E. coli htrA promoter, and is fused in-frame to the E. coli HlyA secretion signal sequence. Also described is Salmonella enterica serovar Typhi strain Ty21a containing the F1-V fusion protein expression plasmid, such as for use as an oral vaccine against plague.
