The invention provides immunogenic compositions useful for inhibiting, treating, protecting, or preventing infection byActinobacillus suis.These immunogenic oompositions are demonstrated to usefully stimulate immunogenic responses in treated pigs. Some vaccines stimulated reactions sufficient to be protective againstA. suis.In addition, the invention provides kits comprising the immunogenic compositions; as well as, methods of using the compositions and kits.本發明提供可用於抑制、治療、防禦或預防豬放線桿菌(Actinobacillus suis)感染之免疫原性組合物。已證實該等免疫原性組合物可在所治療豬中有效地刺激免疫原性應答。有些疫苗刺激之反應足以防禦豬放線桿菌。另外,本發明提供包含該等免疫原性組合物之套組;以及使用該等組合物及套組之方法。