An electrical signal generator (10) for treating a subject suffering from, or at risk of an inflammatory disorder is described. The generator comprises: an electrode assembly comprising electrodes (20a, 20b) for delivering an electrical signal to the vagus nerve of the subject and a controller (16). The controller controls the electrical signal by applying current between the electrodes of the electrode assembly and limiting the applied electrical signal to have a pulse width range of from 0.1 ms to 5 ms a signal frequency range of from 0.1 Hz to 30 Hz, a signal on-time range of from 1 second to 120 seconds and a signal off-time range of from 2 to 48 hours following a signal on-time.
