Cell-based assay for detecting anti-CD3 homodimers

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专利权人:

Inc.;Genentech

发明人:

Kendall Carey

申请号：

US15824992

公开号：

US10690678B2

申请日:

2017.11.28

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention provides a cell-based assay for identifying and/or quantifying anti-CD3 homodimers in a composition comprising a T cell-dependent Bispecific antibody (TDB). In some aspects, the invention T cells comprising a T cell activation responsive reporter are contacted with the TDB to detect the presence of anti-CD3 homodimers. Compositions of reporter T cells and kits are also contemplated.

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