A multi-mix infusion bag is provided. The multi-mix infusion bag includes a lower portion and an upper portion. The lower portion has a lower chamber and the upper portion includes a plurality of chambers. Each chamber is separated and contains a fluid agent. The multi-mix infusion bag is configured to transfer each fluid agent within each chamber of the upper portion into the lower chamber for mixing. The multi-mix infusion bag may include dispensing devices associated with each chamber, wherein the dispensing devices operate to transfer the fluid agents into the lower chamber for mixing.