Methods of use of early apoptotic cell populations and compositions thereofdisclosed herem, including methods oftreating a cancer or a tumor, extending survival times of a subject sufferingfrom a cancer or a tumor, and reducing the size or reducingthe growth rate of a cancer or a tumor, wherein subjects are administeredapoptotic cells or compositions thereof Cancers may includesolid tumors or diffuse cancers, for example leukemia In certain instancescompositions may include additional chemotherapeuticagent Further, inactivated early apoptotic cell populations are disclosed andmethods of making the same