KUZNETSOVA, Irina Nikolaevna;КУЗНЕЦОВА, Ирина Николаевна;SINCHIKHIN, Konstantin;СИНЧИХИН, Константин;KUZNETSOVA, Nadezhda Olegovna;КУЗНЕЦОВА, Надежда Олеговна
发明人:
KUZNETSOVA, Irina Nikolaevna,КУЗНЕЦОВА, Ирина Николаевна,SINCHIKHIN, Konstantin,СИНЧИХИН, Константин,KUZNETSOVA, Nadezhda Olegovna,КУЗНЕЦОВА, Надежда Олеговна
申请号：
RURU2019/000960
公开号：
WO2020/209752A1
申请日:
2019.12.17
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
An emulsion comprises a perfluorocarbon compound perfluorodecalin and a perfluorocarbon additive and phospholipids in the form of liposomes (vesicles) prepared by homogenization under pressure in an aqueous saline medium. The perfluorocarbon additive is a mixture of perfluorinated products perfluorooctyl bromide and perfluorotripropylamine, and the liposomes (vesicles) contain natural oils as an adjuvant. A method for producing the emulsion comprises producing liposomes (vesicles) by homogenization under a pressure of 60 - 120 atm in an aqueous saline medium followed by hot sterilization, homogenizing said perfluorocarbon compounds under pressure in a liposomal form (vesicles) of phospholipids and performing hot sterilization of the prepared emulsion. The emulsion is intended for improving blood oxygen delivery during the treatment of hypoxic conditions, and for preserving isolated perfused organs and tissues. In accordance with the present invention, the stability of the emulsion is increased while particle structures are preserved, which allows an improvement in the quality of the emulsion and the preservation of biocompatibility with a biological medium (blood, plasma, serum and blood substitutes). The shelf life of the emulsion in an unfrozen form at +4C is at least 23 months with the structure of the emulsion being preserved.L'invention concerne une émulsion qui comprend un composé à base de perfluorocarbone de perfluorodécanyle et un additif à base de perfluorocarbone et des phospholipides sous forme de liposomes (vésicules) obtenus par homogénéisation sous pression dans un milieu aqueux salin. Cet additif à base de perfluorocarbone consiste en un mélange de produits perfluorés de perfluorooctylbromure et de perfluorotripropylamine, et les liposomes (vésicules) contiennent des huiles essentielles en qualité d'adjuvant. Le procédé de production d'émulsion consiste à obtenir des liposomes (vésicules) par homogénéisation à une pression de 60-120 atmosphères dans
