TAKAISHI, MAMORU,SATO, NOBUHIRO,SHIBUGUCHI, TOMOYUKI,MOTOKI, TAKAFUMI,TAKAHASHI, YOSHINORI,SASAKI, TAKEO,BRAUNTON, ALAN
申请号:
CA2901168
公开号:
CA2901168A1
申请日:
2014.02.26
申请国别(地区):
CA
年份:
2014
代理人:
摘要:
A compound represented by general formula (I) [wherein R represents a hydrogen atom, a C1-6 alkyl group or the like; R1 represents a C1-6 alkyl group, a C1-6 alkoxy group or the like; R2 represents a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or the like; R3 represents a hydrogen atom, a C1-6 alkyl group or the like; and R4 represents a C1-6 alkyl group or the like] or a pharmaceutically acceptable salt thereof, which is an antagonist of mGluR2 and can be used as a therapeutic agent for neurological disorders associated with mGluR2-associated glutamate dysfunction and diseases, such as Alzheimer's disease.