Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人:
申请号：
EP17151296
公开号：
EP3351544A1
申请日:
2017.01.12
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention relates to novel substituted benzene disulfonamides of formula (I), as well as pharmaceutical compositions containing at least one of these substituted benzene disulfonamides together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said substituted benzene disulfonamides are binding to the prenyl binding pocket of PDE6´ and therefore, are useful for the prophylaxis and treatment of cancer by inhibition of the binding of PDE6´ to farnesylated Ras proteins and thereby, inhibition of oncogenic Ras signaling in cells.
