The cotton variety FM 8270GLB2 is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and cotton lint as well as to hybrid cotton plants and seeds obtained by repeatedly crossing plants of variety FM 8270GLB2 with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of FM 8270GLB2 and to plants of FM 8270GLB2 reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from FM 8270GLB2.