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NOVEL METHOD FOR THE MANUFACTURING OF DI-CHAIN PROTEINS FOR USE IN HUMANS
专利权人:
发明人:
申请号:
EP12808263.3
公开号:
EP2793934B1
申请日:
2012.12.21
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
This invention relates to a novel method for producing di-chain proteins for use in humans from single-chain precursors, including di-chain clostridial neurotoxins. The method comprises the step of expressing a nucleic acid sequence encoding a single-chain precursor comprising a thrombin-cleavage site and the step of cleaving the single-chain precursor with a human factor Xa or a human thrombin, particularly a human thrombin drug product authorized for human therapeutic use. The invention further relates to novel di-chain clostridial neurotoxins and nucleic acid sequences encoding such novel di-chain clostridial neurotoxins.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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