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FUNCTIONAL INFLUENZA VIRUS-LIKE PARTICLES (VLPS)
专利权人:
NOVAVAX INC.
发明人:
ROBINSON, ROBIN, A.,PUSHKO, PETER, M.
申请号:
HK06110664.8
公开号:
HK1091118B
申请日:
2006.09.25
申请国别(地区):
HK
年份:
2012
代理人:
摘要:
Recombinant influenza virus proteins, including influenza capsomers, subviral particles, virus-like particles (VLP), VLP complexes, and/or any portions of thereof, are provided as a vaccine for influenza viruses. The invention is based on the combination of two vaccine technologies: (1) intrinsically safe recombinant vaccine technology, and (2) highly immunogenic, self-assembled protein macromolecules embedded in plasma membranes and comprised of multiple copies of influenza virus structural proteins exhibiting neutralizing epitopes in native conformations. More specifically, this invention relates to the design and production of functional homotypic and heterotypic recombinant influenza virus-like particles (VLPs) comprised of recombinant structural proteins of human influenza virus type A/Sydney/5/94 (H3N2) and/or avian influenza virus type A/Hong Kong/1073/99 (H9N2) in baculovirus-infected insect cells and their application as a vaccine in the prevention of influenza infections and as a laboratory reagent for virus structural studies and clinical diagnostics.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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