A coupling device (1) for the connection of two ends (3, 9) of respective tubular members (2, 5), allowing the contact of the flowing fluid only with elements inside a closed container, circumstances and an inherently easy connection operation, thus it can be carried out, comprising: a closed container (10) housing said ends (3, 9) of respective tubular members (2, 5), one of said tubular members having a flexible terminal section (8) thereof inside said closed container； a mobile connection member (15), coupled at the end of said flexible terminal section (8), having a nozzle (16) apt to be inserted within a receiving end of the other tubular member,-and a cam device, located inside said closed container (10) and apt to be actuated from the outside of said closed container, apt to cooperate with said mobile connection member (15), the cam device causing the insertion and the ejection of said nozzle in and from said receiving end, and the corresponding connection and the disconnection of the two ends.
