Present invention provides a compound of formula, (I) [Formula 1] (Wherein, E and 4, A R 1, R 2, R 3, R is as described herein, respectively) or a pharmaceutically salt, compounds, or their pharmaceutically acceptable acceptable salts can be used in the state and composition containing said compounds, as well as mediated by acid pump antagonistic activity, such as, but not limited to gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), laryngopharynx reflux (NERD), visceral pain Ellison syndrome, non-erosive gastroesophageal reflux disease - infection, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID- induced ulcers, gastritis, and Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger and use methods of treatment, including for the treatment of asthma, cancer, heartburn, nausea, esophagitis, dysphagia, hypersalivation, or airway obstruction, the above-mentioned compounds.本発明は、式(I)【化1】(式中、R1、R2、R3、R4、A及びEは、それぞれ本明細書中に記載された通りである)の化合物、又はその薬学的に許容しうる塩、又は薬学的に許容しうる塩、及び上記化合物を含有する組成物、並びにアシッドポンプアンタゴニスト活性により媒介される状態、例えば、限定されないが胃腸疾患、胃食道疾患、胃食道逆流性疾患(GERD)、咽喉頭逆流症、消化性潰瘍、胃潰瘍、十二指腸潰瘍、NSAID-誘導潰瘍、胃炎、ヘリコバクターピロリの感染、消化不良、機能性消化不良、ゾリンジャー-エリソン症候群、非びらん性胃食道逆流症(NERD)、内臓痛、癌、胸焼け、悪心、食道炎、えん下困難、過流涎、気道障害又はぜん息の処置のための、上記化合物を含む処置方法及び使用に関する。
