A new and distinct cultivar of Rudbeckia plant named ‘;ET RDB 603’;, characterized by its tall and upright to somewhat outwardly spreading and mounded plant habit; relatively small leaves; dense and bushy growth habit; freely flowering habit; large single-type inflorescences with yellow orange and greyed orange bi-colored ray florets positioned above the foliar plane on strong peduncles; and good postproduction and garden performance.