PROBLEM TO BE SOLVED: To obtain a stable percutaneously absorbable type preparation by formulating a nonfunctional tacky agent containing a percutaneously absorbable medicine with a specific discoloring suppressant.SOLUTION: This preparation is obtained by forming a tacky agent layer on at least one surface of a support and including a percutaneously absorbable medicine, 2-mercaptobenzimidazole and/or propyl gallate and a nonfunctional tacky agent in the tacky agent layer. A tacky agent selected from the group of a tacky agent composed of an acrylic polymer, a rubber-based tacky agent, a silicone-based tacky agent, a vinyl ether-based tacky agent and a vinyl ester- based tacky agent is preferably used as the nonfunctional tacky agent. 6- Amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole and its salt are excluded from the percutaneously absorbable medicine.COPYRIGHT: (C)1999,JPO【課題】 経皮吸収性薬物〔6-アミノ-5-クロロ-1-イソプロピル-2-(4-メチル-1-ピペラジニル)ベンズイミダゾールおよびその薬理学的に許容される塩を除く〕を製剤中に安定に存在せしめ、特に経皮吸収性薬物を粘着剤中に配合した際に生じる着色を抑制した経皮吸収型製剤の提供。【解決手段】 経皮吸収性薬物と、2-メルカプトベンズイミダゾールおよび/または没食子酸プロピルと、無官能性粘着剤とを含有してなる粘着剤層が、支持体の少なくとも片面に形成されてなる経皮吸収型製剤。
