Doris Coit;Angelica Medina-Selby;Michael Houghton;Yin-Ling Lin
发明人:
Michael Houghton,Yin-Ling Lin,Angelica Medina-Selby,Doris Coit
申请号：
US12310406
公开号：
US08216590B2
申请日:
2007.08.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides HCV fusion polypeptides including truncated or full-length HCV NS5 polypeptides, and a portion of the HCV NS2 polypeptide, fused to at least one other HCV epitope derived from another region of the HCV polyprotein. The fusions can be used in methods of stimulating an immune response to HCV, for example a cellular immune response to HCV, such as activating hepatitis C virus (HCV)-specific T cells, including CD4+ and CD8+ T cells. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize against HCV.
