Universal carrier for targeting molecules to Gb3 receptor expressing cells

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专利权人:

Ludger Johannes

发明人:

Ludger Johannes,Eric Tartour,Bruno Goud,Wolf Herve Fridman

申请号：

US12569007

公开号：

US08852612B2

申请日:

2009.09.29

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein:STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfhydryl group, n being 0, 1 or a polypeptide,Cys is the amino-acid Cysteine,and the use thereof for MHC class I and MHC class II presentation of antigens.

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