THE ROCKEFELLER UNIVERSITY;ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
发明人:
COLLER, BARRY S.,FILIZOLA, MARTA,FOLEY, MICHAEL ANDREW
申请号：
CA3029829
公开号：
CA3029829A1
申请日:
2017.07.05
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
2-Substituted-4-(5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanamido)butanoic acids are disclosed. These compounds selectively inhibit aVß3 without activating the aVß3 receptor. They are useful for treating osteoporosis, acute myelogenous leukemia, sickle cell disease, focal segmental glomerulosclerosis, fibrosis, supravalvular aortic stenosis associated with Williams syndrome, tumors expressing aVß3, tumor metastasis, bone resorption, T-cell lymphoma, retinal disease, age-related macular degeneration, diabetic retinitis, and herpes simplex virus infection. They may also be used for inhibiting tumor angiogenesis.
