CHU, Daniel,WANG, Bing,FENG, Ying,SHEN, Yuqiao,POST, Leonard Edwin
申请号：
AU2016231573
公开号：
AU2016231573A1
申请日:
2016.09.22
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016231573A120161020.pdf#####ABSTRACT A compound having the structure set forth in Formula (I) and Formula (II) wherein the substituents Y, Z, A, B, R 1, R2, R 3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADPribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity. 108
