Peter H. Seeberger,You Yang,Chakkumkal Anish,Anika Reinhardt
申请号：
US14346858
公开号：
US20140234364A1
申请日:
2012.09.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to the total chemical synthesis of the monosaccharide 35# (R′═H), the disaccharide 36# (R′≠H R″═H), the trisaccharide 37# (R′≠H R″≠H R′″≠H) and the tetrasaccharide 1# (R′≠H R″≠H R′″≠H) of the following general formula wherein R represents —Y—NH2Y represents a linker R′ is H or R″ is H or R′″ is H or of the lipopolysaccharide from Neisseria meningitidis, as well as to the trisaccharide 37# and the tetrasaccharide 1#, to vaccines containing at least one of the saccharides 1#, 35#, 36#, and 37# and to the use of such vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide α-GlcNAc-(1→2)-α-Hep-(1→3)-α-Hep-(1→5)-α-Kdo or the trisaccharide α-Hep-(1→3)-α-Hep-(1→5)-α-Kdo or α-GlcNAc-(1→2)-α-Hep-(1→3)-α-Hep, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.
