FEDERALNOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE "NAUCHNO-ISSLEDOVATELSKIJ INSTITUT NEJROKHIRURGII IMENI AKADEMIKA N.N. BURDENKO" ROSSIJSKOJ AKADEMII MEDITSINSKIKH NAUK
发明人:
POTAPOV ALEKSANDR ALEKSANDROVICH,Потапов Александр Александрович,GAVRILOV ANTON GRIGOREVICH,Гаврилов Антон Григорьевич,GORJAJNOV SERGEJ ALEKSANDROVICH,Горяйнов Сергей Александрович,ZELENKOV PETR VLADI
申请号：
RU2012137062/14
公开号：
RU0002497558C1
申请日:
2012.08.30
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to neurooncology, and may be used for the intraoperative diagnosis of cerebral and spinal tumour borders and determination of the tumour resection quality. What is presented is an intraoperative combined spectroscopic diagnostic technique for cerebral and spinal tumours which involve the preoperative preparation including the oral administration of hydrochloride-5-aminolevulinic acid (several hours before the tumour resection). Actually the intraoperative spectroscopic analysis of the tumour marker content in the analysed tissues (5-aminolevelinic acid-induced protoporphyrin IX), as well as its desintegration products, oxygenated and reduced hemoglobin the tissue scattering properties are varied using broadband and laser geode light source and a fibre-optic probe. The broadband light source is used within the range of 500÷600 nm, while the exiting fluorescent laser/diode light source - at wave length 620÷640 nm. The diffuse-reflectance spectra of the broadband and laser/diode light, as well as fluorescence are recorded at the same time. After the spectroscopic characteristics have been automatically classified, the operative radicality is assessed.EFFECT: presented method enables higher reliability of the intraoperative measurements in neuronavigation, reducing time needed for implementing them, providing deeper probing and simplifying the spectra recording in vivo.4 cl, 9 dwg, 3 exИзобретение относится к медицине, а именно к нейроонкологии, и может быть использовано для интраоперационной диагностики границ опухолей головного и спинного мозга и определения качества резекции опухоли. Предложен способ проведения интраоперационной комбинированной спектроскопической диагностики опухолей головного и спинного мозга, в процессе которого в рамках предоперационной подготовки пациенту перорально вводят раствор гидрохлорид-5-аминолевулиновой кислоты (за несколько часов до начала удаления опухоли). Собственно интра
