Timothy David JONES,Francis Joseph CARR,Tehila BEN-MOSHE,Yair SAPIR,Ilana MANDEL,Gal MARKEL,Jacob SCHACHTER,Rona ORTENBERG,Robert George E. HOLGATE
申请号：
MX2016014048
公开号：
MX366359B
申请日:
2015.04.27
申请国别(地区):
MX
年份:
2019
代理人:
摘要：
Humanized antibodies, capable of specific binding to human CEACAMl molecules containing human-to-murine back-mutations in non-CDR variable regions, and their encoding polynucleotide sequences are provided. Pharmaceutical compositions comprising these antibodies as well as methods of their use in treating and diagnosing cancer and other conditions are also provided.La presente invención se refiere a un anticuerpo monoclonal (mAb) humanizado o un fragmento del mismo, que específicamente reconoce CEACAM1 humana, caracterizado porque comprende: (i) una secuencia de región variable de cadena pesada seleccionada del grupo que consiste de； SEQ ID NO: 28, SEQ ID NO: 29, SEQ ID NO: 30, SEQ ID NO: 31 y SEQ ID NO: 32, Y (ii) una secuencia de región variable cadena ligera seleccionada del grupo que consiste de: SEQ ID NO: 33, SEQ ID NO: 34 o SEQ ID NO: 35.
