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Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof
专利权人:
Amgen Inc.
发明人:
Hu, Shaw-Fen,Foltz, Ian,King, Chadwick Terence,Li, Yang,Arora, Taruna
申请号:
NZ71784710
公开号:
NZ717847A
申请日:
2010.12.03
申请国别(地区):
NZ
年份:
2018
代理人:
摘要:
Disclosed is an isolated antigen binding protein that induces FGF21-mediated signaling, wherein the antigen binding protein comprises: (a) a light chain CDR1 comprising an amino acid sequence at least SEQ ID NO: 167 or a light chain CDR1 sequence that differs by no more than a total of three amino acid additions, substitutions, and/or deletions from SEQ ID NO: 167 (GGNNIGSQSVH); (b) a light chain CDR2 comprising SEQ ID NO: 176 or a light chain CDR2 sequence that differs by no more than a total of three amino acid additions, substitutions, and/or deletions from SEQ ID NO: 176 (DDSDRPS); (c) a light chain CDR3 comprising SEQ ID NO: 190 or a light chain CDR3 sequence that differs by no more than a total of three amino acid additions, substitutions, and/or deletions from SEQ ID NO: 190 (QVWDSSSDHVV); (d) a heavy chain CDR1 comprising SEQ ID NO: 122 or a heavy chain CDR1 sequence that differs by no more than a total of three amino acid additions, substitutions, and/or deletions from SEQ ID NO: 122 (NARMGVS); (e) a heavy chain CDR2 comprising SEQ ID NO: 133 or a heavy chain CDR2 sequence that differs by no more than a total of three amino acid additions, substitutions, and/or deletions from SEQ ID NO: 133 (HIFSNDEKSYSTSLKS); and (f) a heavy chain CDR3 comprising SEQ ID NO: 148 or a heavy chain CDR3 sequence that differs by no more than a total of three amino acid additions, substitutions, and/or deletions from SEQ ID NO: 146 (ILLLGAYYYYGMDV).
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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