MARCINIAK ANDRZEJ,ANDRZEJ MARCINIAK,TURSKI WALDEMAR ANDRZEJ
申请号：
PL387584
公开号：
PL228037B1
申请日:
2009.03.23
申请国别(地区):
PL
年份:
2018
代理人:
摘要：
The invention relates to the use of kynurenic acid derivatives of general formula (I), wherein R1 is hydroxy, NHR2, NR2R2 or C1-10 straight or branched alkoxy or glyceryl group； R2 is hydrogen atom or C1-10 straight or branched alkyl group； R3-R6 are independently of each other hydrogen atom, halogen atom, C1-10 alkyl, C2-10 alkenyl or alkynyl group optionally substituted with a halogen atom, and a pharmaceutically acceptable salt, ester or amide thereof in manufacturing of a drug used in prevention and therapy of pancreas disorders characterized by edema and/or vacuolization and/or destruction of pancreatic tissue and/or pancreas necrosis leading to release of pancreatic &alpha；-amylase. Preferably, in the compound represented by formula (I) R1 is a hydroxy, NH2, NH&mdash；(C1-5 straight or branched alkyl) or C1-5 straight or branched-alkoxy or glyceryl group； R2 is a hydrogen atom； R3-R6 are independently of each other a hydrogen atom, halogen atom or CF3 group. In the most preferred embodiment, the invention concerns the use of kynurenic acid or its pharmaceutically acceptable salt in manufacturing of a drug used in prevention and therapy of pancreas disorders characterized by edema and/or vacuolization and/or destruction of pancreatic tissue and/or pancreas necrosis leading to release of pancreatic &alpha；-amylase.
